Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against Trypanosoma cruzi

Título:

Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against Trypanosoma cruzi

Autor:

David Rodrigues da Rocha

Ano:

2021

DOI:

10.3390/molecules26020423

Revista:

ISSN:

14203049

Idioma:

Português

Buscar essa publicação no Google Acadêmico

Publicações com a mesma autoria

A New Strategy for the Synthesis of Nonsymmetrical 3,3?-(Aryl/alkyl- methylene) bis-2-hydroxy-1,4-naphthoquinones and Their Cytotoxic Effects in PC3 Prostate Cancer Cells

Chagas Disease: Challenges in Developing New Trypanocidal Lead Compounds

Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities

8-Hydroxy-2-(1H-1,2,3-triazol-1-yl)-1,4-naphtoquinone derivatives inhibited P2X7 Receptor-Induced dye uptake into murine Macrophages

Synthesis, molecular docking, and biological activity of thioether derived from juglone in preclinical models of chronic myeloid leukemia

Synthesis and anti-Trypanosoma cruzi Activity of New 3¿Phenylthio-nor-β-lapachone Derivatives

Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor

Addition of thiols to o-quinone methide: New 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7)

Selective and sensitive pull down of amyloid fibrils produced in vitro and in vivo by the use of pentameric-thiophene-coupled resins.

Synthesis of new N,S-acetal analogs derived from juglone with cytotoxic activity against Trypanossoma cruzi